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84,85 In a crossover study of healthy dogs taking the steroid prednisolone, SAMe supplementation at 10 mg/kg body weight twice daily for 42 days was found to reduce blood markers of liver oxidative damage, although the dogs still developed signs of steroid-induced liver disease

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Clarke R, Lewington S, Sherliker P, Armitage J (2007) Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia