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Development of transgenic Paulownia trees expressing antimicrobial thionin genes for enhanced resistance to fungal infections using chitosan nanoparticles

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While early clinical trials showed modest short‐term results, a long‐term study ( N = 795: 494 VNS + treatment as usual, 301 treatment as usual alone) revealed more significant benefits: cumulative 5‐year response rates reached 67.6% versus 40.9% ( p 0.05) (Kox et al