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Many of the effects of insulin and glucose are mediated through adipocytes and adipose tissue, and the vitamin D receptor is abundantly expressed in adipocytes and is involved in their regulation (Clemente-Postigo 2015

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Visible changes in brightness and evenness of skin tone may take several weeks to months, depending on baseline pigmentation, dose, route of administration, and adherence to sun protection.​ Results are often subtle and natural-looking, and ongoing maintenance may be required to sustain benefits, especially in individuals with high sun exposure