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These compounds have been implicated in the pathogenesis and progression of numerous chronic diseases, including T2D, cardiovascular disease, Alzheimer’s disease, and inflammatory bowel diseases ( Research gaps Beyond BMI—better phenotyping Given BMI’s limitations as a proxy for adiposity and metabolic disease risk, adjunct anthropometrics (e.g., waist-to-hip ratio) and body-composition measures (e.g., %BF) may offer clinically useful refinement
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