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A study employing a different dipeptidylpeptidase-4 inhibitor, linagliptin, following AΞ²42 injection to brain ameliorated cognitive impairment, attenuated levels of AΞ²42 oligomers, decreased the degree of insulin resistance (by decreasing levels of phosphorylation of the inhibitory Ser307 site on IRS-1), and diminished levels of GSK-3Ξ² and proinflammatory cytokines and, importantly, decreased levels of oxidative and nitrosative damage in hippocampus
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