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Severe and mild mutations in cis for the Methylenetetrahydrofolate Reductase (MTHFR) gene, and description of five novel mutations in MTHFR

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Treatment with 5-amino-1mq upregulates proliferation‑related genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness