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This seems to be consistent with the fact that higher levels of thiomethyl metabolites were observed in PHH than in HRG cells since CYP2E1 activity in primary human hepatocytes is known to be higher than in HRG cells ( 28 )
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These are the ascorbic acid mannose pathway regulator 1 ( AMR1 ), COP9 Signalosome Subunit 5B ( CSN5B ) and 8 ( CSN8 ), and NBS-LRR 33 ( NL33 )
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