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Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release

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The increase in hepcidin levels during inflammatory stress is primarily mediated by interleukin-6 (IL-6) [77, 78] and signaling via the STAT3 pathway in hepatocytes which results in iron sequestration within iron-recycling macrophages, hypoferremia, and restricted iron availability for erythropoiesis [78, 79] (Fig