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an antibody that specifically binds to an EphA2 polypeptide comprises a VH domain encoded by a nucleic acid sequence having a nucleotide sequence of the VH domain of 12G3H11, B233, B208, B210, G5, 10C12, 4H5, 10G9, 3F2, 1C1, 1F12, 1H3, 1D3, 2B12, or 5A8