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Potential Benefits (preclinical) ▪ Senescent-cell clearance: In aged/progeroid mice, FOXO4-DRI selectively cleared senescent cells via the FOXO4–p53 mechanism [1] [3]

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Namely, NO-inhibition (LNAME-induced retinal ischemia) [13] and NO-over-stimulation (overproduction of NO interacting with oxygen radicals induced the death of retinal neurons) [198,199,200] may be both harmful