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Materials and Methods Materials Cyanocobalamin (5, 6-Dimethylbenzimidazolyl cyanocobamide), Thiamine (3-[(4-Amino–2–methyl–5–pyrimidinyl) methyl]-5-(2–hydroxyethyl)-4–methylthiazolium chloride) and pyridoxine (5-Hydroxy–6–methyl–3,4–pyridinedimethanol) were obtained from Sigma-Aldrich, Germany (Figure 1)