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GLP-1 receptors are expressed in cardiac tissue, kidney tubules, hepatocytes, and neuronal populations, and sema has been used as a research tool to probe the physiological significance of GLP-1R signaling in these organ systems under controlled experimental conditions

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An increase in PGC-1α expression was accompanied by a corresponding increase in the level of the fusion protein Mfn2, while the level of splitting protein levels was significantly reduced (Wang et al., 2019d)