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METABOLIC EFFECTS AND INSULIN SENSITIVITY Glucose Metabolism Insulin sensitivity: improvement in the HOMA-IR index 30-40% Glucose uptake: increased muscle/liver uptake 25% Gluconeogenesis: Modulation of Hepatic Glucose Production HbA1c: reduction of 0.4–0.61 TP3T in diabetic models Plasma Lipid Profile Triglycerides: reduction of 25–35% Total cholesterol: decrease of 10–151 TP3T HDL: increase of 8–121 TP3T LDL: Reduction of small, dense particles 20% ApoB: decrease of 15% Liver Function Hepatic steatosis: reduction in liver fat 40-50% (NMR spectroscopy) ALT/AST: Improves 25-30% markers in NAFLD Hepatic Insulin Sensitivity: Signaling Restoration De novo lipogenesis: inhibition of hepatic lipid synthesis 3

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Scacheri et al., 2004), as well as addressing the issues of sequence-dependent and chemical-dependent toxicity (Grimm et al., 2006