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Also, measures of G6PD activity are generally reflective only of the amount of enzyme, rather than the activity within the cell, because at physiological concentrations of NADPH, G6PD is almost completely inhibited (22)
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Together, these puzzling findings show that HbKO mice possess a significantly decreased susceptibility to EAE compared to WT mice, but the mechanism underlying this difference does not appear to be directly related to primary T-lymphocyte effector functions
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