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In addition, hepatic stellate cells (HSCs) (Ito cells and lipocytes), portal-resident fibroblasts (portal or central veins), epithelial cells undergoing epithelial-to-mesenchymal transition, bone marrow-derived fibroblasts, vascular smooth muscle cells, and sinusoidal peri-hematopoietic stem cells are the main cell types that produce the ECM during hepatic fibrosis[14]
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Although these provide many health benefits, there are still some side effects that may possibly occur
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