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In a mouse model of acute lung injury, pulmonary edema, histological changes, and LPS-mediated inflammatory cytokine production were improved by scoparone in vivo , while in vitro experiments in alveolar macrophages revealed that the compound’s anti-inflammatory effects were mediated through the toll-like receptor 4 (TLR4)/NFκB pathway (150)
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111 These compensatory mechanisms fail when Cd exceeds species-specific thresholds, triggering AsA/GSH synthesis inhibition and irreversible oxidative damage
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