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Reported side effects Mild headache or fatigue – typically transient during initial use Mild gastrointestinal discomfort – reported in some oral formulation users Sleep disruption or irritability – potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway – which promotes cellular growth and repair – there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk