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Notably, more than 95% of Kupffer cells expressed TIM4, a marker of embryonically-derived Kupffer cells 25 , indicating that repopulation by monocyte-derived macrophages (which are typically TIM4 − ) was minimal under these conditions (Supplementary Fig
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This point is very interesting, since recent data suggests that AD should be considered as an affection of the entire organism and not only the brain, possibly having a partial origin in peripheral metabolic alterations [94, 95]
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