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Previous studies have shown that amino acid starvation (e.g., methionine restriction) or lipid dysregulation (e.g., PE/PC imbalance) can trigger the ISR and ER stress-related pathways 26,51,52,53,54

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The film coating efficiently reduces ROS by activating the antioxidant enzymes SOD and G-POX and significantly induces NO production while reducing the l-Pro content and GR activity, whereas the CAT activity remains high when the film with SiNPs is applied