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In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding
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This means that our immune system recognizes the thyroid gland as a foreign invader and begins to attack it, eventually leading to the destruction of our thyroid tissue
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