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Quantification and statistical analysis Prism software package (GraphPad Software 7) was used for statistical analysis with the level of significance of 0.05 (95 % confidence)

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We applied high CIL 10,000 K light as the subjective daytime signal and low CIL 2,000 K light as the subjective nighttime signal at alternating 12 h intervals, denoted as CIL high/CIL low (CH/CL)