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In addition to GPX4, AIFM2 (apoptosis inducing factor mitochondria associated 2) plays a role in mediating the conversion of coenzyme Q 10 (CoQ 10 ) to the reduced form (CoQ 10 H 2 ), which directly prevents lipid peroxidation or indirectly activates the endosomal sorting complex required for transport-III (ESCRT-III) membrane repair system [142–144]