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In a clinical trial, administration of 2600 mg of ALA to 18 patients just before kidney transplantation along with perfusion of the renal grafts with 600 mg of ALA 1 h before transplantation markedly reduced plasma creatinine level and severity of DGF, and prevented renal allograft rejection while increasing MDRD during the first 14 days after kidney transplantation compared to placebo-treated control group (18 patients) (Weber et al., 2017)

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The reduced-to-oxidized glutathione (GSH/GSSG) ratio, an essential indicator of redox homeostasis, is markedly lower in PCOS follicular fluid and granulosa cell samples, reflecting compromised antioxidant regeneration capacity (7)