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It also reduced the expression of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6 in the retina and vitreous humor through the suppression of the phosphorylation of STAT3 and NF-κB, and the binding of 67LR on the neurons and glia [65]

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Therefore, applying dietary restrictions or implementing some drug interventions can induce the regulation of Nrf2/ARE and increase the expression of antioxidant enzymes, such as GSH