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As a dual amylin and calcitonin receptor agonist, cagrilintide’s mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMY₁R, AMY₂R, and AMY₃R – each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively
Semaglutide
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→ Diarrhea or constipation – GI motility changes are similar to what’s seen with semaglutide
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