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Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Eagleson et al., 2016)

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Yet, concomitant inhibition of arrestin 3 expression (arrestin 3 KO mice) and ERK1/2 activity by PD98059 results in reduction of MOR desensitization indicating that this process involves two independent pathways