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BPC 157 also has an effect on blood vessels, resulting in vessel recruitment that circumvents vessel occlusion and the development of additional shunting and rapid bypass loops to rapidly reestablish the integrity of blood flow (ischemic/reperfusion colitis, duodenal lesions, cecal perforation, and inferior vena caval occlusion)

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It is important to note that while many biochemical studies provide support for the disparate structure of these Fe–S clusters in Rrf2 proteins, crystallographic structures have only been reported for holo-NsrR 498 and RsrR