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To test whether this newly identified L1′–FnIII-2′ interaction is functionally important for receptor activation, we introduced multiple mutations in the L1 β hairpin of IGF1R (K164A, T166A, N169A, and Y171A), deleted the entire L1 β hairpin (Δ163–174), or replaced this L1 β hairpin with a short GSGS loop (163GS) to disrupt this interaction

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Option:600mg

doi: 10.1007/s00775-009-0476-x