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In the skin, the balance between the pro- and antioxidant properties of melanin are mainly determined by the relative eumelanin and pheomelanin contents, the levels of melanin intermediates, the concentrations of reactive metals within the melanosome microenvironment (Di Donato et al

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In Canada, the Natural Health Products Ingredients Database (NHPID) lists selenium—in the form of selenocysteine—as an acceptable medicinal ingredient and includes selenium yeast as an entry for NHP formulations

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