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Perturbations in the gut microbiota expose the intestine to inflammatory and genotoxic metabolites such as secondary bile salts, trimethylamine N-oxide, hydrogen sulfide, heme, nitrosamines, heterocyclic amines, and polyaromatic hydrocarbons

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We illustrate the neurophysiological mechanisms underpinning their actions and interactions and present the findings of relevant research studies examining their safety and dose-dependent efficacy

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