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Because the mouse tissues were readily available for study, the investigators were able to evaluate collagen content and fibril morphology in a number of tissues including the aorta
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Together, these data show that FOXO4-DRI potently and selectively reduces the viability of senescent cells by competing with FOXO4-p53 binding, thereby triggering release of active p53 to the cytosol and inducing cell-intrinsic apoptosis through Caspase-3/7
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