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In vitro studies showed that B 12 exerts superoxide dismutase activity, i.e., B 12 can react with superoxide (O 2 − ), producing H 2 O 2 at high rates approaching the reaction rates of the physiological defense enzyme superoxide dismutase [73]

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MOTS-c, along with other mitochondrial-derived peptides (MDPs) like humanin, represents an expanded mitochondrial genetic repertoire with significant biological activities