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2 Mechanisms of action 2,3 CD38-directed therapies work through multiple mechanisms, including: Complement-dependent cytotoxicity (CDC) Antibody-dependent cell-mediated cytotoxicity (ADCC) Antibody-dependent cellular phagocytosis (ADCP) Apoptosis Direct effects Immunomodulatory effects These mechanisms may contribute to the development of resistance to CD38 antibodies

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31 (Suppl 3), S117–S135 (2012)