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It is also possible that our sample size was too small to detect minor genotype-related differences, or that in the context of severe deficiency, everyone is at risk, regardless of genetic background.Notably, the lack of a significant effect of the MTHFR C677T polymorphism on homocysteine levels suggests that severe vitamin deficiencies may override genetic predisposition in this pediatric cohort

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Kumar R., Chaudhary A.K., Woytash J., Inigo J.R., Gokhale A.A., Bshara W., Attwood K., Wang J., Spernyak J.A., Rath E., et al