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Histological and histomorphometry analysis of bone from 8-week-old WT, Gif –/– (F2) /VEH, and Gif –/– (F2) /TAU mice revealed that the low bone mass observed in Gif –/– (F2) /VEH mice was completely rescued in Gif –/– (F2) /TAU mice, due to a major increase in osteoblast number and function, while osteoclast parameters were not affected (Figure 6D and Supplemental Figure 6C)