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SAM facilitates polyamine synthesis by providing propylamine and adding a methyl group for histone methylation (Doench et al., 2003)

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The same page also outlines a broader 1 to 2 mg daily range, often on a 5-days-on/2-days-off pattern over 8 to 12 weeks , plus another schedule of 1.0 to 2.0 mg daily for 30 to 60 days on followed by 30 to 60 days off , and a lower 0.5 to 1.5 mg daily or every other day range