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These interventions should be individualized and biomarker-guided (e.g., endothelial function, Prx redox state, GSH/GSSG, F 2 -isoprostanes, LIP assays) and titrated to preserve beneficial H 2 O 2 -based signalling while preventing convergence onto ONOO − , hydroxyl-radical formation and runaway lipid peroxidation (Frijhoff et al

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