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The low doses of MPH result in slight increases in dopamine and norepinephrine selectively in the prefrontal cortex, while not affecting other brain regions (Berridge et al., However, the dangers of cognitive enhancement with stimulants like MPH lie in their potential effects on the regulation of dopamine and norepinephrine (Figure 2)

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Subsequently, it activated the phosphorylation of VEGFR2, Akt, and eNOS signal pathway without the need for other known ligands or shear stress

While it is typically safe for use