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It’s recommended to take the medication for a maximum of 2 years because of the risk for bone loss
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These compounds prevent IBD by activating/inhibiting multiple signaling pathways, including TGF-β/Smad, TRL-4/NF-κB/MAPK, TLR2-NF-κB, autophagy, pyroptosis, glycolysis/gluconeogenesis and amino acid metabolism, Nrf-2/HO-1, microbiota-macrophage-arginine metabolism, and bile acid metabolism
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