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MAZ51 is a potent inhibitor of VEGFR3 kinase activity, which only weakly affects the related receptor tyrosine kinase VEGFR2 62,63
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When quantifying the levels of kynurenines in patients newly diagnosed with osteoporosis (and therefore receiving no relevant medication at the time), it was found that the serum content of 3-hydroxy-anthranilic acid (3HAA) was substantially lower (around 10-fold) than that in a parallel cohort of normal control subjects
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