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The most dramatic result (mice returning to a body composition indistinguishable from lean age-matched animals) came from combining the inhibitor with a low-fat diet switch, and that study did not include a drug-alone arm

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Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton’s tyrosine kinase,LiYFranklinSZhangM