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These bioactive compounds, available as dietary supplements, functional foods, and fortified products, have gained global popularity due to their natural origins and lower side-effect profiles compared to synthetic drugs (2)

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In addition, differences in myosin heavy chain (MHC) isoform expression and cardiac deiodinase activity may further alter the cardiac response to T3, highlighting the need for caution when extrapolating rodent data to humans (113, 114)