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Challenges in Developing QSIs, Including Specificity and Potential Resistance A significant challenge in the development of QSI arises from the gradual evolution of resistance to QSI in bacteria [208]

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Despite these findings, substrate availability may also play a role in reducing GSH synthesis rates, because Sekhar et al showed partial restoration of RBC-GSH concentrations and absolute synthesis rates in uncontrolled type 2 diabetes after cysteine and glycine supplementation [16]