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B12 (when taken with dexamethasone, an anti-inflammatory steroid medication) has also been shown to increase the activity of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which promote nerve survival and regeneration

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The SELECT trial [1] demonstrated cardiovascular benefits beyond weight loss, showing 20% reduction in major adverse cardiac events (Lincoff et al., NEJM, 2023)