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Among these techniques, microarray is considered to be the most widely used experimental platform for miRNA expression profiling, while qRT- PCR is used for quantification of specific miRNA and genome wide miRNA ( 3.3.2 miRNA profiles in TNBC progression The first study to demonstrate the involvement of miRNA in the development of BC was carried out by Iorio and colleagues who identified altered miRNA expression in BC cells in comparison to non-cancerous cells and the correspondence of many miRNA expression profiles to BC subtypes and clinical pathological features ( Several studies have been undertaken to identify the miRNAs’ expression profiles to distinguish TNBC from other BC subtypes
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