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Such considerations conceivably may contribute to the known greater neurotoxicity of Aβ42 small oligomers relative to those of Aβ40 (126)

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Additionally, esculetin (12.5-25 µg/ml) inhibits the activation of the NF-κB signaling pathway in TNF-α induced vascular smooth muscle cells, which reduces the expression levels of mitochondrial membrane potential-9 (MMP-9) and the binding activity of activating protein-1 (AP-1) (74,75)