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In a phase Ib study, AMT-101 was well tolerated (no incidence of thrombocytopenia or anemia).62 No systemic toxicities were noted, and AMT-101 systemic levels were below the limit of quantitation as expected with the gut selective mechanism of action

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The utilization of nanoparticles in this manner allows them to traverse through biofilms which are typically resistant to traditional antibiotics and directly reach the bacteria, thereby exerting a more potent bactericidal effect [249]