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In fact, the lack of any association between FRA-positive children and other autoimmune markers or autoantibodies points away from the FRA being associated with classical autoimmune disease

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Frailty was associated with greater disability (OR: 5.9[3.9-9.1]), cognitive impairment (OR: 1.8[1.0-3.1]), depression (OR: 2.2[1.4-3.5]) and poorer physical (OR: 5.1[2.6-11.2]) and mental quality of life (OR: 1.7[1.1-2.5]) at 3 months