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For the optic nerve axotomy model, intraperitoneal injections of 50 mg/kg EGCG at 30 min before axotomy, and at Day 2 and 4 after axotomy were able to attenuate RGC loss by 12% in rat retina along with reducing the upregulation of neuronal nitric oxide synthase and Bax protein expression, and further enhancing ERK 1/2 and Akt activation after axotomy [111]

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