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Although taking these meds doesn’t automatically equal deficiency, your doctor should keep an eye on your B12 levels, especially if you’ve been taking acid-blockers for longer than a year or metformin for more than four months, according to an article in the journal, American Family Physician (9)

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(For a full overview of vitamin B12 benefits beyond mood, start with our master guide.) When the brain doesn't have the raw materials it needs to produce neurotransmitters and maintain healthy nerve function, mood is one of the first things to shift